A newfound favorite, Malwarebytes (screenshot, above) is great for rooting spyware/malware infections. The free version works great, and only lacks an automatic update and real time protection (similar to anti-virus programs). We recommend running a full scan the first time around with this app. It is very very good at detecting and removing threats. You may be prompted to reboot your computer (please do so).
spybot
An old reliable, Spybot's been around since 2000 or 2001 when spyware started becoming an issue. When installing Spybot, you can uncheck the TeaTimer box. TeaTimer's a good feature but rather encumbering to an unversed computer user. The first time you run it, you will be prompted thru a one-time wizrd. Make sure you update it, then "Check for problems" and remove any threats it finds.
other anti-spyware apps
Super AntiSpyware, Ad-Aware, Spyware Doctor are all good apps and may be substituted for our recommendation. Beware of similar sounding apps that are actually spyware themselves. Names like WinAntiVirus2009 and SuperSpybot are malware themselves.